As an Amazon Associate I earn from qualifying purchases from

Rating one of the best berberine dietary supplements of 2022

Berberine is an natural complement with a historical past that’s 1000’s of years lengthy.

It’s been used and researched to deal with every little thing from joint pain to weight reduction to controlling diabetes in individuals with insulin insensitivity.

Berberine’s mechanism of motion is complicated, but it surely seems to change the best way your physique’s mitochondria generate power, which could point out why it’s useful for such all kinds of illnesses.

When you’re searching for a high quality weight reduction complement sourced from an natural treatment, berberine is value a glance.

We’ve examined what’s obtainable available on the market proper now and give you the highest ten, ranked based on efficacy.

Why You Ought to Belief Us

    Our advisory panel and our analysis staff rank one of the best well being merchandise and dietary supplements based mostly on efficiency, label accuracy, and the efficacy of the components within the merchandise.


Final up to date: September 22, 2022
Berberine dietary supplements thought-about: 25
Hours of analysis: 45
Specialists reviewed: 10
Scientific papers referenced: 32


Greatest General

1. Nuzena Berberine Pure +

  • Helps coronary heart well being, blood sugar management, and gastrointestinal perform
  • Every veggie capsule boasts 600 mg of extremely pure and extremely concentrated berberine
  • Its purity is independently verified by third-party lab testing
View Latest Price →

Greatest for intestine well being

2. Thorne Analysis Berberine

  • Pure product with a minimal quantity of extraneous components
  • Probably the greatest berberine dietary supplements on the market that is available in a vegetarian capsule
  • 500 mg per capsule
View on Amazon →

Greatest for ladies

3. aSquared Vitamin Berberine

  • Extremely pure berberine complement in a gelatin capsule
  • Offers a really stable 500 mg of berberine per capsule at a 60% focus
  • Has a superb status for purity and high quality in its dietary supplements
View on Amazon →

Greatest for weight reduction

4. Integrative Therapeutics Berberine Complicated

  • It makes use of three completely different plant species as sources of berberine
  • Mixed with a number of of the opposite associated compounds within the plant which can be bioactive
  • Gluten-free
View on Amazon →

5. We Like Nutritional vitamins Berberine

  • It has a simplistic design and allergen-free certification
  • The one different components are gelatin and rice flour
  • Gluten-free, dairy-free, egg-free, and soy free
View on Amazon →

6. Divine Bounty Berberine

  • 600 mg per capsule
  • Offers 20% extra berberine per serving than most of its different opponents
  • It is available in a vegetarian capsule
View on Amazon →

7. Naturebell Berberine Plus

  • Offers a stable berberine complement with a excessive dose of 600 mg per capsule
  • Good purity and complement design
  • Wheat-free, soy-free, dairy-free, and egg-free
View on Amazon →

8. Dr. Whitaker’s Medical Grade Berberine

  • Branded and clinically grade
  • 500 mg of berberine per capsule
  • Gelatin capsule
View on Amazon →
  • Has superior absorption properties
  • 500 mg of berberine per capsule
  • Brown rice focus filler within the vegetarian capsule
View on Amazon →
  • 600 mg berberine complement
  • Vegetarian capsule
  • It’s licensed freed from many widespread allergens like gluten and soy
View on Amazon →

1. Nuzena Berberine Pure +

Check the lowest price

If you wish to leverage the advantages of berberine for higher coronary heart well being, blood sugar management, and gastrointestinal perform, look no additional than Nuzena Berberine Pure +. 

Every veggie capsule boasts 600 mg of extremely pure and extremely concentrated berberine, placing it on the high of our listing thanks each to its excessive dosage and to its excessive purity. On high of that, its purity is independently verified by third-party lab testing, and it’s licensed non-GMO, gluten-free, and vegan-friendly.

For all of those causes, Berberine Pure + by Nuzena is our primary choose for 2021.

Check the lowest price

2. Thorne Analysis Berberine

Check price at Amazon

Thorne Analysis is a well known title within the rarer, much less widespread natural extracts as a result of they virtually all the time make a high quality, pure product with a minimal quantity of extraneous components.

That’s definitely the case right here, as this is among the finest berberine dietary supplements on the market that is available in a vegetarian capsule. At 500 mg per capsule, it doesn’t skimp on the dosage both.

3. Integrative Therapeutics Berberine Complicated

Check price at Amazon

Not like many different firms, Integrative Therapeutics is doing one thing revolutionary with its berberine complement. It makes use of three completely different plant species as sources of berberine, and certainly one of them is mixed with a number of of the opposite associated compounds within the plant which can be bioactive.

Which means that this berberine complement may very well be extra more likely to work if others have failed you, although if all you need is 100% pure berberine, there are higher choices available on the market.

4. NOW Dietary supplements Berberine Glucose Help

Check price at Amazon

NOW Dietary supplements makes a fairly stable berberine complement that’s particularly geared in direction of utilizing berberine for blood sugar management.

It accomplishes this by delivering its berberine content material in MCT oil, a superb ship platform for the lipid-soluble biologically energetic compounds in berberine.

The one draw back? This methodology of supply places a restrict on the dosage; every capsule delivers solely 400 mg of berberine

5. We Like Nutritional vitamins Berberine

Check price at Amazon

The dosage of berberine on this complement (600 mg per capsule) is middle-of-the-road, however its simplistic design and its allergen-free certification make it a really stable selection.

The one different components are gelatin (for the capsule–sorry, vegetarians) and rice flour, and the truth that it’s gluten, dairy, egg, and soy free are all to its profit.

6. Divine Bounty Berberine

Check price at Amazon

For these searching for a excessive dosage berberine complement, Divine Bounty is an effective selection. With 600 mg per capsule, it gives 20% extra berberine per serving than most of its different opponents.

Add to that the truth that it is available in a vegetarian capsule and doesn’t have a lot in the best way of additional fillers and stabilizers, and also you’ve bought a successful system for individuals who want the next than ordinary dose of berberine.

7. Naturebell Berberine Plus

Check price at Amazon

Naturebell gives a stable berberine complement with a excessive dose of 600 mg per capsule, which is sweet for extra aggressive supplementation routines capturing for 1200 mg per day in two separate doses. Other than this, the purity and complement design is sweet however not the best possible.

8. Dr. Whitaker’s Medical Grade Berberine

Check price at Amazon

Although it’s branded as medical grade, this berberine complement doesn’t seem like of upper dosage or high quality than the rest available on the market.

It has the standard 500 mg of berberine per capsule, and the capsules are manufactured from gelatin together with just a few further fillers and stabilizers not discovered within the opponents, making it onerous to justify rating this complement any greater.

9. Toniq Berberine

Check price at Amazon

Toniq delivers a extremely purified model of berberine extract at a stable 500 mg dosage. It’s a terrific go-to choice if you need a easy and pure berberine complement at a typical dosage, although the capsule has just a few extra binders and fillers than we’d prefer to see.

10. Sunergetic Berberine

Check price at Amazon

Sunergentic has a high-dose 600 mg berberine complement that’s delivered in a vegetarian capsule.

It’s additionally licensed freed from many widespread allergens like gluten and soy, although the principle draw back of the berberine complement from this lesser-known complement producer is its reliance on silica as a filler for its capsules. Larger-quality manufacturers will go for one thing extra pure, like rice flour.

Class winners

Greatest berberine total: Nuzena Berberine Pure +

With 600 mg of berberine per capsule, unbiased lab verification for purity, and no extraneous components, Nuzena is a superb selection. Excessive dose, super-pure, and simple to make use of.

Greatest berberine for intestine well being: Thorne Research Berberine

If you’re utilizing berberine for intestine issues, just like the bacterial overgrowth linked to SIBO, you desire a berberine complement that’s freed from any extraneous components. That’s why we suggest Thorne Analysis Berberine for intestine well being—its ultra-simple complement design makes it well-suited for this utility.

Greatest berberine for weight reduction: Integrative Therapeutics Berberine

Integrative Therapeutics gives berberine alongside two different natural extracts for digestive and metabolic well being: goldenseal and Oregon grape extracts. These may very well be helpful for stopping a number of the troublesome gastrointestinal unwanted side effects that may come together with beginning a weight reduction weight-reduction plan. 

Greatest berberine for ladies: NOW Supplements Berberine Glucose Support

Girls profit from the extremely bioavailable supply of berberine on this complement, with simpler absorption because of the MCT oil used to dissolve the energetic compounds in berberine. The five hundred mg dosage is an effective match for a lot of ladies as nicely

Greatest berberine for coronary heart well being: Thorne Research Berberine

Berberine has been utilized in just a few scientific research to scale back blood lipids and blood stress, which may also help lower your threat of coronary heart illness. To observe the protocols from these research as intently as doable, go for a pure and concentrated berberine complement like Thorne Analysis Berberine, which boasts 500 mg of 85% berberine extract.

Greatest berberine for blood sugar management: Nuzena Berberine Pure + 

Considered one of berberine’s hottest purposes helps to manage blood sugar, and the high-dose formulation of Nuzena Berberine Pure + is completely suited to this use case: its 600 mg of concentrated berberine extract per capsule leads the trade in dosage. 

Who should purchase berberine?

Berberine seems to modulate the best way your physique processes and makes use of power. Meaning berberine dietary supplements are tailor-made for just a few particular use circumstances:

Individuals who need to management their blood sugar extra successfully. Berberine has been studied most intently as a approach to assist deal with insulin insensitivity in individuals who have kind two diabetes or who’ve metabolic syndrome. Berberine may make it easier to enhance blood glucose regulation and battle again towards metabolic dysfunction.

Individuals who need to fight the unfavourable well being results of weight problems. By itself, berberine isn’t a incredible weight reduction complement, but it surely does do a reasonably good job serving to to ameliorate the unfavourable well being results related to being chubby.

It’d assist decrease your physique fats proportion, but it surely’s far stronger at bettering well being points generally related to an unhealthy weight-reduction plan and extreme physique weight, corresponding to excessive ldl cholesterol and excessive blood lipids.

Some analysis means that berberine works for weight reduction, however not in addition to a number of the extra high-powered compounds for weight reduction like green tea extract

Individuals with irritable bowel syndrome. Curiously, berberine additionally has a devoted core of advocates amongst individuals who have irritable bowel syndrome.

Whereas the mechanism of motion right here isn’t totally clear, medical analysis does help the usage of berberine to scale back a number of the signs of irritable bowel syndrome, so when you’ve got gastrointestinal issues attributable to IBS, you will have success utilizing berberine as nicely.

How we ranked

Berberine’s specialised makes use of knowledgeable our rating process: since there are a number of medical trials on utilizing berberine, we had been capable of examine the supply mechanism, dosage, and purity of the merchandise we thought-about to the gold normal of what’s utilized in scientific analysis. Particularly, we regarded for:

A give attention to delivering berberine. As a result of berberine is particularly geared in direction of sure well being issues, and since many of the proof for it comes from medical trials that used pure berberine extracts of their experiments, we required the berberine dietary supplements in our rankings to ship solely berberine as their energetic ingredient.

Whereas it’s not essentially true that berberine should be taken to the exclusion of all different dietary supplements, that is how it’s often prescribed in medical analysis. No merchandise that included non-berberine energetic components made it into our rankings.

Proof-based berberine dosage. Subsequent, after specializing in berberine-specific dietary supplements, we regarded on the dosage.

Because the analysis on berberine sometimes makes use of 900-1500 mg every day doses divided up into a number of smaller tablets, we required that the berberine dietary supplements in our rankings ship a dose that was simply parsed out into two or three tablets or capsules per day to succeed in this clinically efficient dosage vary.

Something with lower than 400 or greater than 600 mg per capsule was dropped from consideration.

High quality components and no pointless binders or fillers. Past simply the dosage, we additionally regarded on the purity of the berberine dietary supplements. Did they make the most of unbiased laboratory testing for purity, like Nuzena?

Did the capsules have a clear, easy ingredient design, or had been they bloated with silica and different binders or coloring brokers?

These had been the sorts of issues we thought-about when evaluating the remaining berberine dietary supplements. Whereas a cellulose-based capsule versus a gelatin-based capsule was a pleasant perk (for strict vegetarians and vegans), it wasn’t a core analysis standards.

After pooling outcomes from all of those standards, we had our ultimate rankings of one of the best berberine dietary supplements available on the market. 


Q: What does berberine do for the physique?

A: Berberine primarily acts in your physique’s metabolic setting, serving to to forestall the stresses of a poor weight-reduction plan and the stresses of being chubby or overweight from inflicting will increase in your blood lipids and blood ldl cholesterol.

It additionally exerts a potent stage of management over poorly regulated blood sugar, which is characteristically seen in kind two diabetes and metabolic syndrome.

These mechanisms are pretty well-researched, however berberine additionally seems to exert some direct advantages on weight reduction, and should have advantages for controlling irritable bowel syndrome as nicely—the reasoning behind why it really works in these purposes are much less well-understood.

Q: Can I take berberine and metformin on the identical time?

A: Berberine has been studied together with metformin in a single research (1), and no unfavourable drug interactions had been reported.

Nevertheless, it’s dangerous to take a prescription remedy and a complement which can be imagined to do the identical factor (i.e. decrease blood sugar) on the identical time, since whether or not these medicine work together, or inhibit every others’ mechanism of motion is unknown.

It’s best to discuss to your physician first when you take metformin (or some other prescription drug) and would additionally prefer to attempt berberine alongside it to higher management your blood sugar.

Q: Can berberine have an effect on testosterone ranges?

A: Some primary organic analysis performed in cells on Petri dishes means that sure sorts of cells (largely tumor cells, or ovary cells) could cut back their expression of testosterone and different androgens, however by way of results in your physique total, there’s no proof that berberine will both decrease or boost your testosterone levels.

Q: How lengthy do you have to take berberine?

A: Medical analysis means that getting the advantages of berberine could take six to eight weeks to attain its results, and a number of other research have discovered advantages at twelve weeks as nicely.

Past the timeframe of some months, it’s not clear when you ought to take berberine indefinitely, and any potential long-term well being results haven’t been explored intimately.

Q: Does berberine assist with weight reduction?

A: Some analysis means that berberine could assist with short-term weight reduction, which is nice on condition that we already know berberine will be useful at controlling well being points related to being chubby or overweight.

Whereas it’s not as potent of a weight reduction complement as components like inexperienced tea extract or green coffee bean extract, the advantages are nonetheless welcome if you’re chubby and are taking berberine for metabolic well being. Simply don’t depend on it to do the entire proverbial heavy lifting for you on the subject of reducing weight.

Q: How lengthy does it take for berberine to decrease blood sugar?

A: Most research on berberine for decreasing blood sugar have examined their outcomes at six or eight weeks.

That’s to not say that important variations wouldn’t have emerged if these research had been concluded both, but it surely does recommend that you could be need to be affected person when ready for outcomes from berberine. It’s not essentially going to be a fast in a single day repair, even when it does work.

Associated articles


Berberine has been studied as a pure complement for controlling blood sugar in individuals with metabolic syndrome and kind two diabetes.

Furthermore, it has purposes in controlling a number of the different unfavourable results of weight problems, corresponding to excessive blood ldl cholesterol and excessive blood lipids. Whereas berberine exhibits some promise as a weight reduction product as nicely, its true power is in controlling the metabolic setting in your physique, particularly when it’s harassed by an unhealthy weight-reduction plan or carrying round further weight.

Some rising proof even means that berberine may very well be useful for irritable bowel syndrome, however the causal pathways behind this will not be but clear.

Berberine is pretty secure, with gentle gastrointestinal unwanted side effects like constipation and abdomen ache often reported. Berberine seems to be best when taken at dosage ranges of 900 to 1500 mg per day, break up into two to a few equal doses.

Berberine’s potential for controlling blood sugar, blood lipids, and different indicators of your physique’s metabolic well being is kind of robust, making it one of the crucial thrilling natural dietary supplements available on the market proper now.

For BodyNutrition‘s #1 berberine suggestion, click on here.

We will be happy to hear your thoughts

Leave a reply

Shop Well
Enable registration in settings - general
Compare items
  • Total (0)
Shopping cart